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OCR: KH) test 1 in the The corticotrophin-releasing hormone has become established as a powerful to ng's investigation of ACTH-dependent Cush inistered TH and syndrome: 100ug of synthetic CRH is adr intravenously, with measurement of A minutes for cortisol levels being made every fifteen ecretion two hours. Patients with ectopic ACTH while in fail to respond to stimulation with CRH usually rise Cushing's disease, serum cortisol levels of patients excessively (Fig. 8.14); some ten per cent cteristic with Cushing's disease show an unchar lack of response. thasone The combination of a high-dose dexame es over hing's suppression test with a CRH test identif ninety-five per cent of patients with Cus